Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.78 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.78 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.78 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | AMD1 | P17707 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291671 | 0.90 | PI4KA (0.80) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL20133912 | 0.89 | PI4KA (0.65) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL30586379 | 0.89 | PI4KA (0.78) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL91054 | 0.88 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL20483753 | 0.88 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL24146588 | 0.88 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL21882960 | 0.88 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL22393059 | 0.88 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL9970446 | 0.88 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL18125984 | 0.88 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322715-A1 | BROAD SPECTRUM ANTI-CANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-10-12 | — | — | US | disclosed |
| US-9289383-B2 | Method of reducing intraocular pressure in humans | INOTEK PHARMACEUTICALS CORPORATION (US) | 2016-03-22 | — | — | US | disclosed |
| US-20150080330-A1 | METHOD OF REDUCING INTRAOCULAR PRESSURE IN HUMANS | INOTEK PHARMACEUTICALS CORPORATION | 2015-03-19 | — | — | US | disclosed |
| US-8895530-B2 | Method of reducing intraocular pressure in humans | INOTEK PHARMACEUTICALS CORPORATION (US) | 2014-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080330-A1 | METHOD OF REDUCING INTRAOCULAR PRESSURE IN HUMANS | PDE3A, PDE2A, PDE6C | PI4KA 2449/4885PI4K2B 2948/4885PI4K2A 2186/4885 |
| US-20230322715-A1 | BROAD SPECTRUM ANTI-CANCER COMPOUNDS | YTHDF1, YTHDF3, YTHDF2 | PI4KA 1123/4885PI4K2B 980/4885PI4K2A 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.