Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 1.00 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 1.00 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 1.00 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.66 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.65 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.65 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.65 |
| ▸ | DPP4 | P27487 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.65 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.65 |
| ▸ | GAPDH | P04406 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29803977 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17568786 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL13901805 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL308385 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL18125984 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL13986328 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL24146588 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL22393059 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL20483753 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL29380625 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753433-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210363171-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2021-11-25 | — | — | US | disclosed |
| US-10968247-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2021-04-06 | — | — | US | disclosed |
| US-10663470-B2 | Immunoassay of S-adenosylmethionine in personalized medicine and health or cancer evaluation | HUNAN SKYWORLD BIOTECHNOLOGIES CO (CN) | 2020-05-26 | — | — | US | disclosed |
| US-10656159-B2 | Immunoassays of s-adenosylmethionine and methylation index in personalized medicine and health evaluation | HUNAN SKYWORLD BIOTECHNOLOGIES CO (CN) | 2020-05-19 | — | — | US | disclosed |
| US-20190300562-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2019-10-03 | — | — | US | disclosed |
| US-20180169128-A1 | IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS | HAO, XIUJUAN | 2018-06-21 | — | — | US | disclosed |
| US-20180156816-A1 | IMMUNOASSAYS OF S-ADENOSYLMETHIONINE AND METHYLATION INDEX IN PERSONALIZED MEDICINE AND HEALTH EVALUATION | HAO, XIUJUAN | 2018-06-07 | — | — | US | disclosed |
| US-20180156816-A1 | IMMUNOASSAYS OF S-ADENOSYLMETHIONINE AND METHYLATION INDEX IN PERSONALIZED MEDICINE AND HEALTH EVALUATION | HAO, XIUJUAN | 2018-06-07 | — | — | US | disclosed |
| US-20180134745-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2018-05-17 | — | — | US | disclosed |
| US-9877982-B2 | Immunoassay of S-adenosylmethionine using analogs thereof and personalized therapeutics | Hunan SkyWorld Biotechnologies Co. LTD (CN) | 2018-01-30 | — | — | US | disclosed |
| US-9701707-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20150268231-A1 | IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION | HAO, XIUJUAN | 2015-09-24 | — | — | US | disclosed |
| US-20150268231-A1 | IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION | HAO, XIUJUAN | 2015-09-24 | — | — | US | disclosed |
| WO-2014152566-A2 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-8344115-B2 | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples | HAO, XIUJUAN | 2013-01-01 | — | — | US | disclosed |
| US-8344115-B2 | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples | HAO, XIUJUAN | 2013-01-01 | — | — | US | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20090263879-A1 | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples | HAO, XIUJUAN | 2009-10-22 | — | — | US | disclosed |
| US-20090263879-A1 | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples | HAO, XIUJUAN | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263879-A1 | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples | AHCY, MAT2A, MAT1A | PI4KA 4647/4885PI4K2B 4514/4885PI4K2A 4571/4885 |
| US-10663470-B2 | Immunoassay of S-adenosylmethionine in personalized medicine and health or cancer evaluation | AHCY, BHMT2, BHMT | PI4KA 4749/4885PI4K2B 4857/4885PI4K2A 4822/4885 |
| US-20190300562-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | DOT1L, MECP2, TDP1 | PI4KA 3857/4885PI4K2B 3873/4885PI4K2A 3832/4885 |
| US-20150268231-A1 | IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION | AHCY, BHMT2, BHMT | PI4KA 4749/4885PI4K2B 4857/4885PI4K2A 4822/4885 |
| US-10656159-B2 | Immunoassays of s-adenosylmethionine and methylation index in personalized medicine and health evaluation | AHCY, BHMT, BHMT2 | PI4KA 4510/4885PI4K2B 4811/4885PI4K2A 4739/4885 |
| US-20180169128-A1 | IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS | BHMT2, AHCY, BHMT | PI4KA 4866/4885PI4K2B 4880/4885PI4K2A 4874/4885 |
| US-20210363171-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | DOT1L, MECP2, TDP1 | PI4KA 3857/4885PI4K2B 3873/4885PI4K2A 3832/4885 |
| US-10968247-B2 | Methods of synthesizing substituted purine compounds | DOT1L, MECP2, TDP1 | PI4KA 3857/4885PI4K2B 3873/4885PI4K2A 3832/4885 |
| US-11753433-B2 | Methods of synthesizing substituted purine compounds | DOT1L, MECP2, TDP1 | PI4KA 3857/4885PI4K2B 3873/4885PI4K2A 3832/4885 |
| US-20180134745-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | DOT1L, MECP2, TDP1 | PI4KA 3857/4885PI4K2B 3873/4885PI4K2A 3832/4885 |
| US-20180156816-A1 | IMMUNOASSAYS OF S-ADENOSYLMETHIONINE AND METHYLATION INDEX IN PERSONALIZED MEDICINE AND HEALTH EVALUATION | AHCY, BHMT, BHMT2 | PI4KA 4510/4885PI4K2B 4811/4885PI4K2A 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.