Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 16/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692262 | 0.80 | CCR4 (0.46) | CCR4DPP4INPPL1ESR1ESR2 | |
| SCHEMBL16692263 | 0.79 | CCR4 (0.45) | CCR4DPP4INPPL1ESR1ESR2 | |
| SCHEMBL18534006 | 0.79 | CCR4 (0.45) | CCR4DPP4INPPL1ESR1ESR2 | |
| SCHEMBL18533995 | 0.78 | ACHE (0.39) | CCR4ACHE | |
| SCHEMBL16258648 | 0.78 | CCR4 (0.51) | CCR4 | |
| SCHEMBL16241952 | 0.78 | CCR4 (0.80) | CCR4 | |
| SCHEMBL16241953 | 0.78 | CCR4 (0.80) | CCR4 | |
| SCHEMBL16258705 | 0.77 | CCR4 (0.67) | CCR4DPP4INPPL1ACHE | |
| SCHEMBL16242203 | 0.77 | CCR4 (0.63) | CCR4 | |
| SCHEMBL16242204 | 0.77 | CCR4 (0.63) | CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493453-B2 | Piperazinyl pyrimidine derivatives, preparation method and use thereof | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2016-11-15 | — | — | US | disclosed |
| US-9493453-B2 | Piperazinyl pyrimidine derivatives, preparation method and use thereof | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2016-11-15 | — | — | US | disclosed |
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-07 | — | — | US | disclosed |
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-07 | — | — | US | disclosed |
| EP-2805947-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2014-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | CCR4, CCR1, CCR3 | CCR4 1/4885DPP4 65/4885INPPL1 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.