Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18869082 | 0.85 | RAB9A (0.49) | TDP1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL16245709 | 0.71 | RAB9A (0.51) | TDP1L3MBTL1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL17831344 | 0.71 | MAPT (0.51) | L3MBTL1HDAC8HDAC1HDAC6HPGD | |
| SCHEMBL30601905 | 0.71 | TDP1 (0.77) | TDP1L3MBTL1ACHEKMT2A | |
| SCHEMBL26626717 | 0.71 | TDP1 (0.77) | TDP1L3MBTL1ACHEKMT2A | |
| SCHEMBL30601923 | 0.69 | TDP1 (0.77) | TDP1L3MBTL1HDAC8HDAC3HDAC4 | |
| SCHEMBL26626715 | 0.69 | TDP1 (0.77) | TDP1L3MBTL1HDAC8HDAC3HDAC4 | |
| SCHEMBL17827730 | 0.69 | PIN1 (0.58) | HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL9219707 | 0.68 | TDP1 (1.00) | TDP1L3MBTL1ACHE | |
| SCHEMBL5093425 | 0.68 | TDP1 (1.00) | TDP1L3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180524-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-13 | — | — | WO | disclosed |