Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL9308 | 0.98 | ALDH1A1 (0.43) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL9158420 | 0.95 | ALDH1A1 (0.41) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL27802159 | 0.95 | ALDH1A1 (0.41) | ALDH1A1AKT1AKT2NOTUMATM | |
| Tetrazole SCHEMBL29023855 | 0.95 | ALDH1A1 (0.41) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL28349299 | 0.91 | AKT2 (0.38) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL28359469 | 0.91 | ALDH1A1 (0.38) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL27894946 | 0.90 | AKT1 (0.36) | ALDH1A1AKT1AKT2NOTUMATM | |
| Biphenyl SCHEMBL28518040 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1AKT1AKT2ALOX15KDM4E | |
| Tetrazole SCHEMBL28320883 | 0.86 | NPC1 (0.43) | ALDH1A1RAB9ANPC1KDM4EMAPT | |
| Biphenyl-4-Amine SCHEMBL28165279 | 0.86 | HSD17B10 (0.56) | ALDH1A1ATMALOX15CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9354239-B2 | BLID; protein domain for interaction with the Bcl-2 family of proteins | WITTE-HOFFMANN CARLOS (US) | 2016-05-31 | — | — | US | claimed |
| US-9346868-B2 | BLID; a novel protein domain for interaction with the Bcl-2 family of proteins. Applications in oncology | WITTE-HOFFMANN CARLOS (US) | 2016-05-24 | — | — | US | claimed |
| EP-0720657-B1 | BIOLOGICALLY RELEVANT METHODS FOR THE RAPID DETERMINATION OF STERILITY | 3M INNOVATIVE PROPERTIES CO (US) | 2007-08-15 | — | — | EP | claimed |
| CN-1326880-C | G-CSF receptor agonist antibodies and methods of screening same | TANOX INC (US) | 2007-07-18 | — | — | CN | claimed |
| EP-0720657-A4 | BIOLOGICALLY RELEVANT METHODS FOR THE RAPID DETERMINATION OF STERILITY | 3M INNOVATIVE PROPERTIES CO (US) | 2004-08-04 | — | — | EP | claimed |
| EP-0720657-A1 | BIOLOGICALLY RELEVANT METHODS FOR THE RAPID DETERMINATION OF STERILITY | NORTH AMERICAN SCIENCE ASSOCIATES INCORPORATED (US) | 1996-07-10 | — | — | EP | claimed |
| US-5486459-A | Biologically relevant methods for the rapid determination of sterility | MEDICAL COLLEGE OF OHIO (US) | 1996-01-23 | — | — | US | claimed |
| WO-1995008639-A1 | BIOLOGICALLY RELEVANT METHODS FOR THE RAPID DETERMINATION OF STERILITY | NORTH AMERICAN SCIENCE ASSOCIATES, INC. (US) | 1995-03-30 | — | — | WO | claimed |
| US-20260001910-A1 | PEPTIDES AND USES THEREOF | PREVECEUTICAL MEDICAL INC (CA) | 2026-01-01 | — | — | US | disclosed |
| CN-120136932-A | Metal compound capable of improving stability and preparation method and application thereof | 浙江海利得新材料股份有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-119950489-A | Nanoparticle for inducing iron death as well as preparation method and application thereof | 三亚中心医院(海南省第三人民医院、三亚中心医院医疗集团总院) | 2025-05-09 | — | — | CN | disclosed |
| US-20250109096-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2025-04-03 | — | — | US | disclosed |
| CN-119607178-A | Application of lamprey transcription factor MKX in preparation of medicine for promoting spinal cord injury repair | 辽宁师范大学 | 2025-03-14 | — | — | CN | disclosed |
| CN-119587528-A | Application of BF4 in preparation of medicines for treating gastric cancer | 深圳大学 | 2025-03-11 | — | — | CN | disclosed |
| CN-1073936-A | The benzenemethanamine derivatives of alpha-substitution | JANSSEN PHARMACEUTICA NV (BE) | 1993-07-07 | — | — | CN | disclosed |
| CN-1073942-A | The benzenemethanamine derivatives of heterocyclic substituted | JANSSEN PHARMACEUTICA NV (BE) | 1993-07-07 | — | — | CN | disclosed |
| CN-1058958-A | HIV inhibiting phenylacetamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1992-02-26 | — | — | CN | disclosed |
| CN-1057840-A | New antiviral imidazolidine is [1,4] benzodiazepine-2-(sulphur) ketone also | JANSSEN PHARMACEUTICA NV (BE) | 1992-01-15 | — | — | CN | disclosed |
| EP-0426167-A2 | Antitumor substance, process for preparing the same, and pharmaceutical composition containing the same | MEIJI SEIKA KAISHA LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| CN-1050192-A | Prepare the also method of [1,4] benzodiazepine of antiviral imidazolidine | JANSSEN PHARMACEUTICA NV (BE) | 1991-03-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001910-A1 | PEPTIDES AND USES THEREOF | MMP3, PEPD, MMP9 | ALDH1A1 3511/4885AKT1 1323/4885AKT2 981/4885 |
| US-20250109096-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | LSS, ERG28, CYP51A1 | ALDH1A1 4312/4885AKT1 2750/4885AKT2 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.