Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.33 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.33 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL174876 | 0.84 | HTR2C (0.59) | ALDH1A1LMNATAAR1HTR2AHTR2C | |
| Orotic Acid SCHEMBL175081 | 0.83 | ALDH1A1 (0.62) | ALDH1A1LMNAHTR2CHTR2BTSHR | |
| Glycolic Acid SCHEMBL162065 | 0.79 | TAAR1 (0.47) | ALDH1A1TAAR1HTR2AHTR2CHTR2B | |
| Succinic Acid SCHEMBL161276 | 0.79 | TAAR1 (0.47) | ALDH1A1TAAR1HTR2AHTR2CHTR2B | |
| Malonic Acid SCHEMBL160930 | 0.79 | TAAR1 (0.47) | ALDH1A1TAAR1HTR2AHTR2CHTR2B | |
| SCHEMBL162669 | 0.79 | HTR2C (0.57) | TAAR1HTR2AHTR2CHTR2BADRA2C | |
| SCHEMBL163850 | 0.79 | HTR2C (0.57) | TAAR1HTR2AHTR2CHTR2BADRA2C | |
| Fumaric Acid SCHEMBL159722 | 0.78 | TAAR1 (0.46) | LMNATAAR1HTR2AHTR2CHTR2B | |
| Maleic Acid SCHEMBL161822 | 0.78 | TAAR1 (0.46) | LMNATAAR1HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL161200 | 0.77 | HTR2C (0.56) | TAAR1HTR2AHTR2CHTR2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |