Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 8/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.36 |
| ▸ | WNT1 | P04628 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22053089 | 0.84 | KMO (0.44) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28434856 | 0.79 | CYP19A1 (0.44) | BRD4METNPC1RAB9AQPCT | |
| SCHEMBL1631431 | 0.78 | NPC1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL26835293 | 0.72 | BRD4 (0.42) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1628889 | 0.72 | MAPT (0.46) | GSK3BDYRK1AWNT1NPC1EGFR | |
| SCHEMBL17795637 | 0.72 | GSK3B (0.46) | GSK3BDYRK1AWNT1KCNH2KMO | |
| SCHEMBL25589659 | 0.71 | ALDH1A1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22052731 | 0.71 | NPC1 (0.40) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22040204 | 0.69 | PSEN1 (0.37) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29132951 | 0.69 | NR1I2 (0.42) | BRD4METGSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2038288-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| WO-2008000697-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENO[3,2]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | UQCRB, UQCRC2, AURKB | BRD4 541/4885PSEN1 4672/4885PSEN2 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.