Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296407 | 0.69 | GLA (0.35) | CA12CA9CA1CA2CA4 | |
| SCHEMBL17505102 | 0.62 | EP300 (0.46) | — | |
| Hydrochloric Acid SCHEMBL19207894 | 0.61 | EP300 (0.45) | — | |
| SCHEMBL10622839 | 0.57 | POLB (0.46) | — | |
| SCHEMBL1955970 | 0.57 | ALDH1A1 (0.45) | DAOPDE7AAADATCA12CA9 | |
| SCHEMBL31716917 | 0.56 | KMT2A (0.42) | AADAT | |
| SCHEMBL11823699 | 0.56 | MEN1 (0.44) | AADAT | |
| SCHEMBL15639226 | 0.56 | LMNA (0.37) | PDE7AAADATCES2CES1 | |
| SCHEMBL4794214 | 0.54 | PKM (0.35) | PDE7AAADATCES2CES1 | |
| SCHEMBL746343 | 0.53 | ALDH1A1 (0.54) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | disclosed |