Sugi Predict

Sugi Predict / Compounds / SCHEMBL16296830

SCHEMBL16296830

SCHEMBL16296830

NC1=C(NS(=O)(=O)c2ccc(Br)s2)C(=O)c2ccccc2C1=O

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 2/20 0.51
▸ ALDH1A1 P00352 5/20 0.48
▸ LMNA P02545 4/20 0.48
▸ TSHR P16473 2/20 0.48
▸ MEN1 O00255 5/20 0.47
▸ KMT2A Q03164 5/20 0.47
▸ HTT P42858 2/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ POLB P06746 2/20 0.45
▸ PKM P14618 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ MAPT P10636 2/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ NSD2 O96028 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ NFKBIA P25963 1/20 0.42
▸ RELA Q04206 1/20 0.42
▸ SLC40A1 Q9NP59 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16296992 0.83 THRB (0.51) THRBALDH1A1LMNATSHRMEN1
SCHEMBL16296725 0.78 MAPT (0.57) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16297080 0.76 MEN1 (0.66) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16296892 0.75 NAT1 (0.63) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16296689 0.75 MAPT (0.55) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16296929 0.74 MAPT (0.71) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16296707 0.74 MAPT (0.72) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL16296760 0.74 NAT1 (0.66) LMNAMEN1KMT2AMAPK1POLB
SCHEMBL16296821 0.72 MITF (0.69) ALDH1A1LMNAMEN1KMT2AMAPK1
SCHEMBL463907 0.71 THRB (0.65) THRBALDH1A1LMNATSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170334842-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY UNIVERSITY OF KANSAS 2017-11-23 — — US disclosed
US-20170334842-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY UNIVERSITY OF KANSAS 2017-11-23 — — US disclosed
US-9745261-B2 Inhibitors of the MITF molecular pathway THE GENERAL HOSPITAL CORPORATION (US) 2017-08-29 — — US disclosed
US-9745261-B2 Inhibitors of the MITF molecular pathway THE GENERAL HOSPITAL CORPORATION (US) 2017-08-29 — — US disclosed
US-20160130222-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY THE BROAD INSTITUTE, INC. 2016-05-12 — — US disclosed
US-20160130222-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY THE BROAD INSTITUTE, INC. 2016-05-12 — — US disclosed
EP-3007688-A2 INHIBITORS OF THE MITF MOLECULAR PATHWAY The General Hospital Corporation (US) 2016-04-20 — — EP disclosed
WO-2014201016-A2 INHIBITORS OF THE MITF MOLECULAR PATHWAY THE GENERAL HOSPITAL CORPORATION (US) 2014-12-18 — — WO disclosed
WO-2014201016-A2 INHIBITORS OF THE MITF MOLECULAR PATHWAY THE GENERAL HOSPITAL CORPORATION (US) 2014-12-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160130222-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY MITF, TFEB, TYR THRB 387/4885ALDH1A1 2501/4885LMNA 3621/4885
US-20170334842-A1 INHIBITORS OF THE MITF MOLECULAR PATHWAY MITF, TFEB, TYR THRB 380/4885ALDH1A1 2444/4885LMNA 3726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.