Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21509220 | 0.88 | SPHK2 (0.42) | SPHK2SPHK1THRB | |
| SCHEMBL16299512 | 0.83 | SPHK2 (0.42) | SPHK2SPHK1SIGMAR1ALB | |
| SCHEMBL16299572 | 0.83 | SIGMAR1 (0.40) | SPHK2SPHK1SIGMAR1TRPV1 | |
| SCHEMBL11549188 | 0.80 | TRPA1 (0.51) | SIGMAR1TRPA1TRPV1 | |
| SCHEMBL1004906 | 0.74 | CA2 (0.50) | SPHK2SPHK1SIGMAR1 | |
| SCHEMBL101260 | 0.74 | TRPA1 (0.58) | SIGMAR1TRPA1TRPV1 | |
| SCHEMBL5908935 | 0.74 | SIGMAR1 (0.40) | SPHK2SPHK1SIGMAR1ALB | |
| SCHEMBL13260231 | 0.74 | SIGMAR1 (0.47) | SPHK2SPHK1SIGMAR1ALB | |
| SCHEMBL5243221 | 0.73 | CYP3A4 (0.46) | SPHK2SPHK1SIGMAR1 | |
| SCHEMBL27370822 | 0.73 | TRPA1 (0.61) | SIGMAR1TRPA1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |