Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56865 | 0.89 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2ELANELIPE | |
| SCHEMBL7866352 | 0.89 | MEN1 (0.50) | APPKMT2AMEN1ELANE | |
| SCHEMBL1639316 | 0.83 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2ELANELIPE | |
| SCHEMBL815429 | 0.81 | TAAR1 (0.51) | KMT2AMEN1SMN1; SMN2ELANEMAPT | |
| SCHEMBL10339728 | 0.79 | ELANE (0.66) | KMT2AMEN1SMN1; SMN2ELANEHPGD | |
| SCHEMBL6255843 | 0.79 | PPARA (0.49) | KMT2AMEN1SMN1; SMN2ELANELIPE | |
| SCHEMBL10885797 | 0.79 | LMNA (0.57) | KMT2AMEN1SMN1; SMN2ELANEHPGD | |
| SCHEMBL1598439 | 0.77 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2ELANELIPE | |
| SCHEMBL6937289 | 0.77 | KMT2A (0.48) | APPKMT2AMEN1SMN1; SMN2ELANE | |
| SCHEMBL8315899 | 0.76 | TPMT (0.41) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |