Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16314625 | 0.89 | HTR1D (0.44) | HTR1DHTR6MTNR1BMTNR1ASLC6A2 | |
| SCHEMBL16302691 | 0.81 | HTR1D (0.51) | HTR1DHTR6MTNR1BMTNR1ACNR1 | |
| SCHEMBL16302689 | 0.75 | HTR1D (0.44) | HTR1DHTR6MTNR1BMTNR1ACNR1 | |
| SCHEMBL8947058 | 0.72 | HTR6 (0.68) | HTR1DHTR6MTNR1BMTNR1ASLC6A2 | |
| SCHEMBL8946953 | 0.69 | MTNR1A (0.68) | HTR1DHTR6MTNR1BMTNR1ASLC6A2 | |
| SCHEMBL16313330 | 0.69 | MTNR1B (0.48) | HTR1DHTR6MTNR1BMTNR1ACNR1 | |
| SCHEMBL25620291 | 0.68 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL16299526 | 0.68 | CYP19A1 (0.53) | HTR1DHTR6MTNR1BMTNR1A | |
| SCHEMBL16313373 | 0.67 | CYP19A1 (0.49) | HTR1DHTR6MTNR1BMTNR1ACNR1 | |
| SCHEMBL25620287 | 0.67 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |