Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16302691 | 0.81 | HTR1D (0.51) | CYP19A1HTR6HTR1DMAPTMTNR1B | |
| SCHEMBL7749049 | 0.78 | TBXAS1 (0.52) | HTR6HTR1DKDM4EMAPTMTNR1B | |
| SCHEMBL16302689 | 0.76 | HTR1D (0.44) | CYP19A1HTR6HTR1DMTNR1BMTNR1A | |
| SCHEMBL7613059 | 0.75 | KDM4E (0.64) | HTR6HTR1DKDM4EMAPTKMT2A | |
| SCHEMBL8947058 | 0.74 | HTR6 (0.68) | HTR6HTR1DKDM4EMAPTKMT2A | |
| SCHEMBL9210352 | 0.74 | HTR6 (0.50) | HTR6HTR1DKDM4EMAPTKMT2A | |
| SCHEMBL29128851 | 0.70 | HTR6 (0.52) | HTR6HTR1DKDM4EMAPTKMT2A | |
| SCHEMBL21478112 | 0.68 | HTR1D (0.50) | HTR6HTR1DKDM4EMAPTKMT2A | |
| SCHEMBL16299520 | 0.68 | HTR1D (0.44) | HTR6HTR1DMTNR1BMTNR1A | |
| SCHEMBL4490559 | 0.68 | CYP19A1 (0.42) | CYP19A1HTR6MTNR1BMTNR1ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |