Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29128851 | 0.85 | HTR6 (0.52) | HTR6HTR1DKDM4EKMT2AMAPT | |
| SCHEMBL7613059 | 0.82 | KDM4E (0.64) | HTR6HTR1DMTNR1AMTNR1BKDM4E | |
| SCHEMBL16299526 | 0.74 | CYP19A1 (0.53) | HTR6HTR1DMTNR1AMTNR1BKDM4E | |
| SCHEMBL8508265 | 0.73 | KDM4E (0.56) | HTR6HTR1DKDM4EKMT2AMAPT | |
| SCHEMBL1424220 | 0.71 | ALDH1A1 (0.69) | HTR6HTR1DKDM4EMAPTALDH1A1 | |
| SCHEMBL29415611 | 0.71 | ALDH1A1 (0.69) | HTR6HTR1DKDM4EMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7401442 | 0.70 | LTA4H (0.55) | HTR6HTR1DKDM4EMAPTTRPM8 | |
| SCHEMBL8947088 | 0.70 | HTR6 (0.73) | HTR6HTR1DMTNR1AMTNR1BKDM4E | |
| SCHEMBL9300309 | 0.70 | HTR6 (0.49) | HTR6HTR1DMTNR1AMTNR1BKDM4E | |
| Hydrochloric Acid SCHEMBL273338 | 0.69 | ALDH1A1 (0.67) | HTR6HTR1DKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |