Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739146 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTHSD17B10HPGDMAPT | |
| SCHEMBL11426739 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2HTTHSD17B10MAPTNPSR1 | |
| SCHEMBL7658940 | 0.80 | GAA (0.45) | HTTMAPTPTGS2ALDH1A1KDM4E | |
| SCHEMBL7658960 | 0.80 | GAA (0.41) | PTGS2MEN1KMT2AGAAMAPK14 | |
| SCHEMBL7656019 | 0.80 | GAA (0.41) | HTTMAPTPTGS2KDM4EMEN1 | |
| SCHEMBL11662825 | 0.78 | MAPK14 (0.51) | HTTMAPTPTGS2KDM4EMEN1 | |
| SCHEMBL7655803 | 0.77 | MAPK14 (0.40) | SMN1; SMN2PTGS2KDM4EPOLBMEN1 | |
| SCHEMBL11310203 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2HTTHSD17B10HPGDMAPT | |
| SCHEMBL738697 | 0.77 | MAPT (0.54) | SMN1; SMN2HTTHSD17B10HPGDMAPT | |
| SCHEMBL11425997 | 0.76 | KDM4E (0.39) | SMN1; SMN2HTTHSD17B10MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |