Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116241 | 0.87 | POLB (0.49) | GAAPOLBRAD52ALDH1A1BRD4 | |
| SCHEMBL7656019 | 0.83 | GAA (0.41) | GAAPTGS2PDK1PDK2PDK3 | |
| SCHEMBL7658960 | 0.83 | GAA (0.41) | GAAPTGS2PDK1PDK2PDK3 | |
| SCHEMBL11662825 | 0.80 | MAPK14 (0.51) | GAAPTGS2PDK1PDK2PDK3 | |
| SCHEMBL7655803 | 0.80 | MAPK14 (0.40) | GAAPOLBPTGS2PDK1PDK2 | |
| SCHEMBL16301207 | 0.80 | SMN1; SMN2 (0.51) | GAAPOLBPTGS2ALDH1A1MAPK14 | |
| SCHEMBL11508928 | 0.79 | POLB (0.42) | GAAPOLBRAD52ALDH1A1LMNA | |
| SCHEMBL7650705 | 0.79 | GAA (0.39) | GAAPTGS2PDK1PDK2PDK3 | |
| SCHEMBL28054991 | 0.78 | PTGS2 (0.46) | POLBRAD52PTGS2ALDH1A1BRD4 | |
| SCHEMBL7656523 | 0.76 | PTGS2 (0.37) | GAAPOLBPTGS2ALDH1A1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |