Sugi Predict

Sugi Predict / Compounds / SCHEMBL1630491

SCHEMBL1630491

SCHEMBL1630491

COc1cc(Br)cc(F)c1C=O

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 5/20 0.50
▸ PRKDC P78527 1/20 0.47
▸ ALDH1A1 P00352 4/20 0.38
▸ TSHR P16473 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ LMNA P02545 1/20 0.36
▸ ALOX15 P16050 1/20 0.35
▸ ALOX12 P18054 1/20 0.35
▸ APP P05067 1/20 0.35
▸ MAOA P21397 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ HTR6 P50406 1/20 0.34
▸ PIM1 P11309 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL16268999 0.98 ERN1 (0.49) ERN1PRKDCALDH1A1TSHRKDM4E
Phenol SCHEMBL28563309 0.87 ERN1 (0.47) ERN1PRKDCALDH1A1GAA
SCHEMBL15981125 0.86 ERN1 (0.58) ERN1PRKDCALDH1A1TSHRKDM4E
SCHEMBL21046473 0.82 ERN1 (0.37) ERN1PRKDCALDH1A1TSHRCYP1A2
SCHEMBL18366 0.81 ERN1 (0.46) ERN1PRKDCALDH1A1TSHRKDM4E
SCHEMBL16269455 0.81 PRKDC (0.55) ERN1PRKDCALDH1A1TSHRKDM4E
SCHEMBL16269517 0.81 LMNA (0.51) ERN1ALDH1A1TSHRKDM4ECYP1A2
SCHEMBL16268750 0.80 ERN1 (0.36) ERN1PRKDCALDH1A1KDM4ECYP1A2
SCHEMBL578367 0.80 ERN1 (0.37) ERN1PRKDCALDH1A1
SCHEMBL1645590 0.79 ERN1 (0.62) ERN1PRKDCALDH1A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138978-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIV (US) 2026-05-21 — — US disclosed
US-20250368667-A1 USP1 INHIBITOR SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE LTD (CN) 2025-12-04 — — US disclosed
US-20250361238-A1 1,4-DIPHENYL-1H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER SOPONPONG JAKAPUN (TH) 2025-11-27 — — US disclosed
EP-4229045-B1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER BROAD INST INC (US) 2025-11-12 — — EP disclosed
EP-4582427-A1 USP1 INHIBITOR Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) 2025-07-09 — — EP disclosed
EP-4547336-A1 USP1 INHIBITORS AND USES THEREOF Zentaur Therapeutics USA Inc. (US) 2025-05-07 — — EP disclosed
CN-119823124-A Compounds for targeted degradation of BRD9 C4医药公司 2025-04-15 — — CN disclosed
CN-119836421-A USP1 inhibitors and uses thereof 森韬医药美国公司 2025-04-15 — — CN disclosed
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2025-03-13 — — US disclosed
WO-2025029075-A1 NOVEL BIPHENYL DERIVATIVE AS PD-L1 INHIBITOR (주)아이랩 2025-02-06 — — WO disclosed
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators CORBETT JEFFREY W (US) 2011-12-29 — — US disclosed
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators CORBETT JEFFREY W (US) 2011-12-29 — — US disclosed
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators CORBETT JEFFREY W (US) 2011-12-29 — — US disclosed
US-7932284-B2 Indole sulfonamide modulators of progesterone receptors ELI LILLY AND COMPANY (US) 2011-04-26 — — US disclosed
WO-2010103438-A1 SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS PFIZER INC. (US) 2010-09-16 — — WO disclosed
WO-2010103438-A1 SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS PFIZER INC. (US) 2010-09-16 — — WO disclosed
US-20090069400-A1 Indole Sulfonamide Modulators of Progesterone Receptors ELI LILLY AND COMPANY 2009-03-12 — — US disclosed
EP-1979314-A2 INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS Eli Lilly & Company (US) 2008-10-15 — — EP disclosed
WO-2007087488-A9 INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS LILLY CO ELI (US) 2008-08-28 — — WO disclosed
WO-2007087488-A2 INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS ELI LILLY AND COMPANY (US) 2007-08-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069400-A1 Indole Sulfonamide Modulators of Progesterone Receptors PGR, NPSR1, PRLHR ERN1 1466/4885PRKDC 4598/4885ALDH1A1 837/4885
US-20250368667-A1 USP1 INHIBITOR USP1, USP2, USP28 ERN1 289/4885PRKDC 2263/4885ALDH1A1 644/4885
US-20250361238-A1 1,4-DIPHENYL-1H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER PDCD1, CD274, PDCD1LG2 ERN1 3031/4885PRKDC 2263/4885ALDH1A1 36/4885
US-20260138978-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 CHRM1, CHRM4, CHRM2 ERN1 2044/4885PRKDC 3518/4885ALDH1A1 1029/4885
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators GCKR, GCK, GALK1 ERN1 671/4885PRKDC 797/4885ALDH1A1 1454/4885
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 ERN1 1469/4885PRKDC 1857/4885ALDH1A1 4303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.