Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19880348 | 0.81 | APP (0.55) | MAPTKDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL13590994 | 0.77 | ALOX5 (0.62) | APPMEN1KMT2A | |
| SCHEMBL8994752 | 0.77 | SNCA (0.47) | HSD17B10ALOX15APPMEN1LMNA | |
| SCHEMBL16317470 | 0.77 | APP (0.59) | MAPTSMN1; SMN2ALOX15APPMEN1 | |
| SCHEMBL326717 | 0.75 | ALOX5 (0.64) | MAPTKDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL19314123 | 0.74 | HSD17B1 (0.55) | APPTP53CYP3A4 | |
| Methyl Alcohol SCHEMBL6759181 | 0.73 | ALDH1A1 (0.69) | MAPTSMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL11547412 | 0.73 | ALDH1A1 (0.79) | MAPTSMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL124209 | 0.73 | ALDH1A1 (0.79) | MAPTSMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL2066079 | 0.73 | ERN1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | MAPT 13/4885SMN1; SMN2 388/4885KDM4E 1627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.