Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19880348 | 0.90 | APP (0.55) | SNCAAPPALOX5QDPRCYP3A4 | |
| SCHEMBL19314123 | 0.82 | HSD17B1 (0.55) | APPCYP3A4HSD17B1HSD17B2ESR1 | |
| SCHEMBL19428392 | 0.82 | TTR (0.65) | SNCATTRALBALOX15HSD17B10 | |
| SCHEMBL13590994 | 0.81 | ALOX5 (0.62) | APPALOX5MEN1KMT2AHSD17B1 | |
| SCHEMBL326717 | 0.79 | ALOX5 (0.64) | APPALOX5CYP3A4ALOX15HSD17B10 | |
| SCHEMBL18855325 | 0.79 | TTR (0.61) | SNCATTRALBALOX15HSD17B10 | |
| SCHEMBL8994783 | 0.78 | ESR1 (0.62) | TTRALOX5MEN1KMT2AHSD17B1 | |
| SCHEMBL16317469 | 0.77 | MAPT (0.44) | APPCYP3A4ALOX15HSD17B10MEN1 | |
| SCHEMBL5493701 | 0.76 | APP (0.41) | SNCAAPPALOX5QDPRCYP3A4 | |
| SCHEMBL7929549 | 0.73 | CRHBP (0.54) | TTRALOX5ALBALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585404-A | ANTIARRHYTHMIA AGENT | KARO BIO AB (SE) | 1996-12-17 | — | — | US | disclosed |
| US-5567728-A | BENZOYL BENZOFURAN DERIVATIVES USED TO PREVENT OR TREAT CARDIAC ARRHYTHMIA | KAROBIO AKTIEBOLAG (SE) | 1996-10-22 | — | — | US | disclosed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |