Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.52 |
| ▸ | XDH | P47989 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319492 | 0.83 | SLC22A12 (0.53) | SLC22A12EZH2 | |
| SCHEMBL16319927 | 0.83 | LMNA (0.60) | LMNAMAPK1HTTRAB9ATSHR | |
| SCHEMBL4151526 | 0.80 | HPGD (0.51) | ALDH1A1HPGDSLC22A12XDHAR | |
| SCHEMBL16319183 | 0.79 | LPAR1 (0.57) | ALDH1A1 | |
| SCHEMBL28032622 | 0.78 | CA12 (0.53) | ALDH1A1LMNAMAPK1HTTRAB9A | |
| SCHEMBL1419879 | 0.76 | ALDH1A1 (0.62) | ALDH1A1HPGDXDHLMNAMAPK1 | |
| SCHEMBL1402221 | 0.76 | ALDH1A1 (0.74) | ALDH1A1HPGDXDHLMNAHTT | |
| SCHEMBL3586801 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDRAB9AMRGPRX4 | |
| SCHEMBL4828827 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDXDHRAB9AMRGPRX4 | |
| SCHEMBL177429 | 0.73 | ALDH1A1 (0.84) | ALDH1A1HPGDXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |