Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.57 |
| ▸ | LPAR5 | Q9H1C0 | 5/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319519 | 0.86 | SLC6A4 (0.50) | LPAR1LPAR5PTGER4PTGER2SLC6A4 | |
| SCHEMBL16319927 | 0.84 | LMNA (0.60) | LPAR1LPAR5 | |
| SCHEMBL27150812 | 0.82 | RXRA (0.56) | LPAR1LPAR5PTGER4PTGER2TTR | |
| SCHEMBL16319882 | 0.82 | SLC6A4 (0.49) | LPAR1LPAR5PTGER4PTGER2SLC6A4 | |
| SCHEMBL1750329 | 0.81 | PTGER4 (0.56) | LPAR1LPAR5PTGER4PTGER2TTR | |
| SCHEMBL16319538 | 0.80 | SLC6A4 (0.50) | PTGER4PTGER2SLC6A4HTR2AKCNH2 | |
| SCHEMBL11604036 | 0.79 | RXRA (0.56) | LPAR1LPAR5PTGER4PTGER2NR4A2 | |
| SCHEMBL16319176 | 0.79 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL26936440 | 0.78 | TTR (0.75) | LPAR1LPAR5PTGER4PTGER2TTR | |
| SCHEMBL28032622 | 0.77 | CA12 (0.53) | TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |