Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 9/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319786 | 0.95 | AR (0.45) | ESRRAARSLC22A12EGFRERBB2 | |
| SCHEMBL16319638 | 0.83 | SLC22A12 (0.48) | ARSLC22A12EGFRERBB2SCN8A | |
| SCHEMBL365994 | 0.82 | AR (0.46) | ESRRAARSLC22A12SCN8ASCN10A | |
| SCHEMBL365037 | 0.78 | SLC22A12 (0.48) | ARSLC22A12HSD17B10 | |
| SCHEMBL16319451 | 0.77 | AR (0.46) | ARSLC22A12 | |
| SCHEMBL2379685 | 0.77 | ALDH1A1 (0.56) | ESRRAAREGFRERBB2RAB9A | |
| SCHEMBL5656320 | 0.77 | AR (0.50) | ESRRAARCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL16319488 | 0.76 | SLC22A12 (0.39) | ARSLC22A12EGFRERBB2CYP2D6 | |
| SCHEMBL11963120 | 0.76 | TRPV4 (0.50) | ARSLC22A12TRPV4 | |
| SCHEMBL16319803 | 0.76 | SLC6A4 (0.44) | ARSLC22A12EGFRERBB2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |