Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 11/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365994 | 0.95 | AR (0.46) | ARSLC22A12 | |
| SCHEMBL16319786 | 0.82 | AR (0.45) | ARSLC22A12PGRKDM4EUSP2 | |
| SCHEMBL365037 | 0.81 | SLC22A12 (0.48) | ARSLC22A12KDM4EUSP2ALDH1A1 | |
| SCHEMBL16319803 | 0.79 | SLC6A4 (0.44) | ARSLC22A12KDM4EUSP2ALDH1A1 | |
| SCHEMBL16319665 | 0.77 | ESRRA (0.47) | ARSLC22A12 | |
| SCHEMBL16319638 | 0.76 | SLC22A12 (0.48) | ARSLC22A12KDM4EUSP2ALDH1A1 | |
| SCHEMBL16319403 | 0.74 | EPAS1 (0.38) | ARSLC22A12KDM4EALDH1A1 | |
| SCHEMBL16319488 | 0.74 | SLC22A12 (0.39) | ARSLC22A12KDM4EUSP2ALDH1A1 | |
| SCHEMBL11963120 | 0.74 | TRPV4 (0.50) | ARSLC22A12KDM4EUSP2ALDH1A1 | |
| SCHEMBL12422184 | 0.74 | CA12 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |