Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365037 | 0.86 | SLC22A12 (0.48) | SLC22A12ARKDM4EALDH1A1USP2 | |
| SCHEMBL16319488 | 0.84 | SLC22A12 (0.39) | SLC6A4SLC22A12S1PR3EGFRERBB2 | |
| SCHEMBL16319403 | 0.81 | EPAS1 (0.38) | SLC6A4SLC22A12SLC6A2KCNH2AR | |
| SCHEMBL16319786 | 0.81 | AR (0.45) | SLC22A12EGFRERBB2ARKDM4E | |
| SCHEMBL16319638 | 0.80 | SLC22A12 (0.48) | SLC22A12EGFRERBB2ARKDM4E | |
| SCHEMBL16319451 | 0.79 | AR (0.46) | SLC22A12ARKDM4EALDH1A1USP2 | |
| SCHEMBL11963120 | 0.78 | TRPV4 (0.50) | SLC22A12ARKDM4EALDH1A1USP2 | |
| SCHEMBL16174914 | 0.77 | SLC22A12 (0.43) | SLC6A4SLC22A12SLC6A2ARALDH1A1 | |
| SCHEMBL16319665 | 0.76 | ESRRA (0.47) | SLC6A4SLC22A12EGFRERBB2SLC6A2 | |
| SCHEMBL16319445 | 0.74 | SLC6A2 (0.49) | SLC6A4SLC6A2SLC6A3KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |