Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.52 |
| ▸ | GCG | P01275 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366221 | 0.88 | HDAC3 (0.49) | SCN9AGCGHDAC3HDAC4HDAC1 | |
| Diethylamine SCHEMBL14890048 | 0.84 | GCG (0.47) | SCN9AGCGHDAC3HDAC4HDAC1 | |
| SCHEMBL681092 | 0.83 | PTGS2 (0.51) | SCN9AGCGHDAC3HDAC4HDAC1 | |
| SCHEMBL678827 | 0.72 | SCN9A (0.58) | SCN9AHDAC3HDAC1HDAC2SCN5A | |
| SCHEMBL1594558 | 0.72 | RAB9A (0.60) | GCGHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL680717 | 0.71 | MAPK14 (0.56) | SCN9ASCN5AKDM4ERAB9A | |
| SCHEMBL680594 | 0.71 | SCN9A (0.52) | SCN9AHDAC8SCN5A | |
| SCHEMBL680289 | 0.71 | MCL1 (0.70) | SCN9AALDH1A1RAB9A | |
| SCHEMBL703171 | 0.71 | BCL2L1 (0.59) | SCN9AHDAC1SCN5APTGS2 | |
| SCHEMBL371116 | 0.71 | SCN9A (0.67) | SCN9AHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |