Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | SCN2B | O60939 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319187 | 0.85 | MAPK14 (0.56) | MAPK14SCN9ASCN5APTPN1SMN1; SMN2 | |
| SCHEMBL680193 | 0.84 | MRGPRX4 (0.61) | SCN9AMRGPRX4SCN2BSCN1ASCN1B | |
| SCHEMBL678831 | 0.83 | BCL2L1 (0.52) | SCN9ASCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL2649695 | 0.82 | MAPK14 (0.64) | MAPK14MAPTGAARAB9ATLR7 | |
| SCHEMBL680286 | 0.82 | PGR (0.60) | SCN9ASCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL680466 | 0.82 | EZH2 (0.54) | SCN9ASCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL679345 | 0.81 | SCN9A (0.51) | SCN9AMRGPRX4SCN2BSCN1ASCN1B | |
| SCHEMBL30744927 | 0.81 | NPSR1 (0.61) | SCN9AMRGPRX4SCN2BSCN1ASCN1B | |
| SCHEMBL363886 | 0.81 | MAOB (0.69) | MAPK14MRGPRX4MAPTMMP13HTT | |
| SCHEMBL17940326 | 0.81 | SCN9A (0.62) | SCN9AMRGPRX4SCN2BSCN1ASCN1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MAPK14 1576/4885SCN9A 13/4885MRGPRX4 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.