Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319803 | 0.84 | SLC6A4 (0.44) | SLC22A12SRCEGFRERBB2SLC6A4 | |
| SCHEMBL11963120 | 0.82 | TRPV4 (0.50) | SLC22A12TRPV4HTR2AKDM4EUSP2 | |
| SCHEMBL16319638 | 0.81 | SLC22A12 (0.48) | SLC22A12EGFRERBB2KDM4EUSP2 | |
| SCHEMBL365037 | 0.81 | SLC22A12 (0.48) | SLC22A12KDM4EUSP2ALDH1A1AR | |
| SCHEMBL2472257 | 0.80 | ALDH1A1 (0.43) | SLC22A12SRCTRPV4EGFRERBB2 | |
| SCHEMBL30266491 | 0.80 | TRPV4 (0.47) | TRPV4EGFRERBB2HTR2AKDM4E | |
| SCHEMBL10537256 | 0.80 | TRPV4 (0.47) | TRPV4EGFRERBB2HTR2AKDM4E | |
| SCHEMBL21691198 | 0.77 | CYP2D6 (0.48) | SRCEGFRERBB2SLC6A4HTR2A | |
| SCHEMBL31376036 | 0.77 | CYP2D6 (0.48) | SRCEGFRERBB2SLC6A4HTR2A | |
| SCHEMBL16319665 | 0.76 | ESRRA (0.47) | SLC22A12TRPV4EGFRERBB2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |