Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.58 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319948 | 0.86 | SCN9A (0.51) | ARSCN9ASCN5A | |
| SCHEMBL680594 | 0.83 | SCN9A (0.52) | SCN9ASCN5A | |
| SCHEMBL371116 | 0.82 | SCN9A (0.67) | SCN9ASCN5A | |
| SCHEMBL680332 | 0.82 | SCN9A (0.53) | ARSCN9ASCN5A | |
| SCHEMBL16319655 | 0.82 | PLA2G7 (0.62) | ARPLA2G7SCN9ASCN5A | |
| SCHEMBL4174817 | 0.82 | AR (0.68) | ARESRRA | |
| SCHEMBL365304 | 0.80 | SCN9A (0.46) | ARSCN9ASCN5A | |
| SCHEMBL680479 | 0.77 | SCN9A (0.50) | ARPLA2G7SCN9ASCN5A | |
| SCHEMBL680717 | 0.76 | MAPK14 (0.56) | ARSCN9ASCN5A | |
| SCHEMBL679345 | 0.75 | SCN9A (0.51) | PLA2G7SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |