Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | ARAF | P10398 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319599 | 0.90 | SCN9A (0.52) | SCN9ANOTUMPLA2G7KDRMRGPRX4 | |
| SCHEMBL364772 | 0.87 | RAF1 (0.53) | SCN9ANOTUMKDRLMNAGAA | |
| SCHEMBL16319785 | 0.86 | PLA2G7 (0.55) | ESRRASCN9APLA2G7MRGPRX4RAF1 | |
| SCHEMBL197395 | 0.84 | NOTUM (0.62) | NOTUMKDRMRGPRX4LMNAGAA | |
| SCHEMBL16319487 | 0.82 | SCN9A (0.65) | ESRRASCN9APLA2G7MRGPRX4SCN5A | |
| SCHEMBL370483 | 0.80 | USP2 (0.49) | ESRRASCN9ALMNAMAPTUSP2 | |
| SCHEMBL16319732 | 0.78 | SCN9A (0.48) | SCN9ANOTUMKDRLMNAGAA | |
| SCHEMBL28144725 | 0.78 | NOTUM (0.67) | NOTUMMRGPRX4LMNAGAAMAPT | |
| SCHEMBL27534851 | 0.77 | TTR (0.54) | MRGPRX4GAAMAPTUSP2 | |
| SCHEMBL14649867 | 0.77 | AR (0.53) | ESRRASCN9APLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |