Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | ARAF | P10398 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320297 | 0.90 | ESRRA (0.52) | SCN9ANOTUMPLA2G7KDRBRAF | |
| SCHEMBL16319690 | 0.86 | PLA2G7 (0.53) | SCN9APLA2G7KDRBRAFRAF1 | |
| SCHEMBL364772 | 0.85 | RAF1 (0.53) | SCN9ANOTUMKDRBRAFRAF1 | |
| SCHEMBL16319499 | 0.83 | SCN9A (0.63) | SCN9APLA2G7MRGPRX4SCN5A | |
| SCHEMBL197395 | 0.82 | NOTUM (0.62) | NOTUMKDRMRGPRX4LMNAGAA | |
| SCHEMBL21628831 | 0.81 | MAPT (0.55) | NOTUMMRGPRX4LMNAMAPTRAB9A | |
| SCHEMBL9901570 | 0.78 | PLA2G7 (0.49) | SCN9APLA2G7KDRBRAF | |
| SCHEMBL21628782 | 0.77 | TDP1 (0.54) | NOTUMLMNAMAPTRAB9A | |
| SCHEMBL21628770 | 0.77 | ALDH1A1 (0.51) | NOTUMLMNAMAPTRAB9A | |
| SCHEMBL21628850 | 0.77 | ALDH1A1 (0.51) | NOTUMMRGPRX4LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |