SCHEMBL16320863

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL16003806	0.87	KDM4E (0.42)	TGFBR1CDK2DYRK1ADYRK1BKDM4E
	SCHEMBL16352279	0.84	TGFBR1 (0.38)	TGFBR1CDK2DYRK1ADYRK1BKDM4E
	SCHEMBL16003794	0.84	TGFBR1 (0.38)	TGFBR1CDK2DYRK1ADYRK1BKDM4E
	SCHEMBL16323484	0.82	PDE10A (0.46)	KDM4EALDH1A1POLBGAAAPOBEC3A
	SCHEMBL16320446	0.79	TGFBR1 (0.50)	TGFBR1PDE10A
	SCHEMBL8227604	0.78	DYRK1A (0.41)	TGFBR1CDK2DYRK1ADYRK1BKDM4E
	SCHEMBL16561362	0.78	PDE10A (0.47)	TGFBR1KDM4EALDH1A1POLBGAA
	SCHEMBL16561138	0.77	PDE10A (0.45)	TGFBR1KDM4EALDH1A1POLBMAPT
	SCHEMBL18916737	0.76	MAPT (0.34)	DYRK1AKDM4EALDH1A1MAPTTYK2
	SCHEMBL18916805	0.75	GAA (0.41)	GAALMNAPDE10AHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.