Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 6/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634500 | 0.90 | SYK (0.49) | SYKNTRK1IKBKBCA1CA2 | |
| SCHEMBL1632055 | 0.87 | CCNE1 (0.46) | SYKIKBKBCDK2CDK1CCNT1 | |
| SCHEMBL1632276 | 0.83 | NTRK1 (0.42) | SYKNTRK1TBK1IKBKEIKBKB | |
| SCHEMBL1632397 | 0.82 | TBK1 (0.57) | NTRK1TBK1IKBKEIKBKBCA1 | |
| SCHEMBL1632901 | 0.80 | SYK (0.51) | SYKIKBKBCA1CA2CA9 | |
| SCHEMBL1632502 | 0.80 | ALDH1A1 (0.46) | SYKIKBKBCA1CA2CA9 | |
| SCHEMBL13498245 | 0.79 | CDK2 (0.48) | NTRK1IKBKBCA1CA2CA9 | |
| SCHEMBL1632503 | 0.78 | CDK2 (0.46) | SYKIKBKBCA1CA2CA9 | |
| SCHEMBL1632328 | 0.78 | CA2 (0.50) | NTRK1IKBKBCA1CA2CA9 | |
| SCHEMBL1633586 | 0.77 | CA1 (0.51) | SYKNTRK1IKBKBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |