Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 12/20 | 0.46 |
| ▸ | CDK1 | P06493 | 10/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 8/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.44 |
| ▸ | CDK7 | P50613 | 6/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | CCNH | P51946 | 4/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.44 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632121 | 0.90 | SYK (0.45) | SYKCA1CA2CA4CA9 | |
| SCHEMBL1632055 | 0.89 | CCNE1 (0.46) | SYKCDK2CDK1CCNE1IKBKB | |
| SCHEMBL1632328 | 0.81 | CA2 (0.50) | CA1CA2CA4CA9CDK2 | |
| SCHEMBL1633835 | 0.81 | IKBKB (0.47) | CA1CA2CA4CA9CDK2 | |
| SCHEMBL13498245 | 0.80 | CDK2 (0.48) | CA1CA2CA4CA9CDK2 | |
| SCHEMBL1632502 | 0.79 | ALDH1A1 (0.46) | SYKCA1CA2CA4CA9 | |
| SCHEMBL1634743 | 0.78 | TNIK (0.55) | SYKCA1CA2CA4CA9 | |
| SCHEMBL1633586 | 0.78 | CA1 (0.51) | SYKCA1CA2CA4CA9 | |
| SCHEMBL1633321 | 0.78 | CA1 (0.48) | CA1CA2CA4CA9CDK2 | |
| SCHEMBL1634279 | 0.78 | IKBKB (0.47) | SYKCA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | SYK 4204/4885CA1 4702/4885CA2 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.