Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1631787 | 0.96 | GBA1 (0.51) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1630927 | 0.95 | GBA1 (0.45) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1632673 | 0.94 | GBA1 (0.47) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1630574 | 0.93 | GBA1 (0.43) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1631999 | 0.93 | GBA1 (0.43) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1631448 | 0.90 | GBA1 (0.42) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1632694 | 0.90 | GBA1 (0.42) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1632639 | 0.90 | ROCK2 (0.42) | GBA1CSNK2A2CSNK2A1SCN9ARPS6KB1 | |
| SCHEMBL1631757 | 0.89 | GBA1 (0.43) | GBA1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL1631376 | 0.89 | PDPK1 (0.41) | GBA1CSNK2A2CSNK2A1RPS6KB1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012126-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. | 2009-01-08 | — | — | US | claimed |
| US-7932270-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090012126-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012126-A1 | Certain chemical entities, compositions, and methods | MYLK, MYH2, MYH10 | GBA1 4031/4885CSNK2A2 595/4885CSNK2A1 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.