Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.48 |
| ▸ | PRKDC | P78527 | 12/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332447 | 0.91 | PIK3CA (0.58) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332287 | 0.85 | GABRG2 (0.57) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331826 | 0.83 | GABRG2 (0.50) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331646 | 0.82 | GABRG2 (0.46) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16332428 | 0.78 | GABRG2 (0.50) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332664 | 0.74 | GABRG2 (0.55) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332413 | 0.73 | RHOA (0.47) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16331891 | 0.73 | GABRG2 (0.52) | GABRG2GABRB3GABRA5PIK3CATTK | |
| SCHEMBL16332798 | 0.73 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GRIN1GRIN2B | |
| SCHEMBL16331879 | 0.73 | GABRG2 (0.45) | GABRG2GABRB3GABRA5PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |