Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ABL2 | P42684 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331677 | 0.83 | BRAF (0.45) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16332276 | 0.82 | GABRG2 (0.67) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16332292 | 0.81 | BRAF (0.47) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16332223 | 0.81 | SMN1; SMN2 (0.44) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16331745 | 0.79 | BRAF (0.42) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16332185 | 0.78 | PTK2 (0.52) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16331809 | 0.78 | IGF1R (0.42) | BRAFMEN1KMT2AIGF1REGFR | |
| SCHEMBL16332447 | 0.78 | PIK3CA (0.58) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16332664 | 0.77 | GABRG2 (0.55) | GABRG2GABRB3GABRA5IDH1EGFR | |
| SCHEMBL16332413 | 0.77 | RHOA (0.47) | GABRG2GABRB3GABRA5EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |