Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 13/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331443 | 0.84 | RHOA (0.51) | RHOAABCB1ABCC1ABCG2 | |
| SCHEMBL16331810 | 0.83 | RHOA (0.45) | RHOAEGFRSYK | |
| SCHEMBL16332414 | 0.82 | GABRG2 (0.54) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16332371 | 0.81 | RHOA (0.45) | RHOA | |
| SCHEMBL16332664 | 0.80 | GABRG2 (0.55) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16332798 | 0.79 | GABRG2 (0.46) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16332306 | 0.78 | RHOA (0.54) | RHOATRPV1ABCB1ABCC1ABCG2 | |
| SCHEMBL16332454 | 0.78 | L3MBTL1 (0.44) | RHOA | |
| SCHEMBL16331385 | 0.78 | FYN (0.49) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16332594 | 0.78 | LMNA (0.40) | RHOAGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |