Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 11/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332930 | 0.92 | GABRG2 (0.68) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331495 | 0.82 | CYP1A2 (0.53) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332414 | 0.81 | GABRG2 (0.54) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16331385 | 0.81 | FYN (0.49) | GABRG2GABRB3GABRA5FLT3EGFR | |
| SCHEMBL16332413 | 0.80 | RHOA (0.47) | GABRG2GABRB3GABRA5EGFR | |
| SCHEMBL16331723 | 0.79 | BRAF (0.43) | PIK3CAPRKDCMTORFLT3EGFR | |
| SCHEMBL16332798 | 0.78 | GABRG2 (0.46) | GABRG2GABRB3GABRA5FLT3EGFR | |
| SCHEMBL16331646 | 0.77 | GABRG2 (0.46) | GABRG2GABRB3GABRA5EGFRIDH1 | |
| SCHEMBL16331626 | 0.75 | GABRG2 (0.52) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332276 | 0.74 | GABRG2 (0.67) | GABRG2GABRB3GABRA5PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |