Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331809 | 0.91 | IGF1R (0.42) | IGF1RALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL16331731 | 0.89 | TRPC5 (0.47) | TP53RAB9AIGF1RALDH1A1TSHR | |
| SCHEMBL16331960 | 0.86 | CSF1R (0.46) | TP53RAB9AIGF1RALDH1A1TSHR | |
| SCHEMBL16331429 | 0.83 | ALDH1A1 (0.42) | TP53RAB9AALDH1A1TSHRMAPT | |
| SCHEMBL16332829 | 0.81 | TRPC5 (0.40) | SHMT2RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL16332347 | 0.81 | EGFR (0.44) | TP53SHMT2IGF1RTSHRMAPT | |
| SCHEMBL16332751 | 0.80 | IGF1R (0.44) | IGF1RALDH1A1MAPTPKMHPGD | |
| SCHEMBL16332134 | 0.80 | SMN1; SMN2 (0.52) | TP53RAB9AALDH1A1TSHRMAPT | |
| SCHEMBL16332223 | 0.79 | SMN1; SMN2 (0.44) | IGF1RALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL16332395 | 0.79 | LMNA (0.47) | TP53ALDH1A1TSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |