Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331731 | 0.86 | TRPC5 (0.47) | TRPC5CDK2SRCSMN1; SMN2L3MBTL1 | |
| SCHEMBL16331809 | 0.83 | IGF1R (0.42) | TRPC5CDK2KDRSMN1; SMN2LMNA | |
| SCHEMBL16332667 | 0.81 | TP53 (0.42) | TRPC5CDK4LMNAALDH1A1KDM4E | |
| SCHEMBL16332944 | 0.81 | TRPC5 (0.44) | TRPC5CDK2CDK4ALDH1A1HPGD | |
| SCHEMBL16331429 | 0.75 | ALDH1A1 (0.42) | CLK1CLK2CLK3CLK4L3MBTL1 | |
| SCHEMBL16332751 | 0.75 | IGF1R (0.44) | SRCL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL16332496 | 0.71 | GABRG2 (0.47) | CLK4SRCSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL16332608 | 0.70 | KIF11 (0.46) | LMNAKDM4EMAPT | |
| SCHEMBL16332494 | 0.70 | LMNA (0.47) | CLK4SMN1; SMN2L3MBTL1LMNAALDH1A1 | |
| SCHEMBL16332487 | 0.69 | CYP3A4 (0.51) | CLK4SMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |