Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12542895 | 0.91 | ALDH1A1 (0.57) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL12544175 | 0.89 | ALDH1A1 (0.58) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL316093 | 0.84 | KMT2A (0.76) | ALDH1A1POLBGAAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4846563 | 0.83 | KMT2A (0.73) | ALDH1A1POLBGAAKMT2AMEN1 | |
| SCHEMBL12543204 | 0.83 | KMT2A (0.51) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL2930011 | 0.82 | POLB (0.63) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL6315186 | 0.82 | TDO2 (0.49) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL6069148 | 0.81 | SMN1; SMN2 (0.62) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL5424589 | 0.80 | MKNK1 (0.58) | ALDH1A1POLBKDM4EL3MBTL1GAA | |
| SCHEMBL23830221 | 0.79 | ALDH1A1 (0.47) | ALDH1A1POLBKDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| CN-101346372-B | Aryl-isoxazol-4-yl-oxadiazole derivatives | HOFFMANN LA ROCHE | 2011-09-28 | — | — | CN | disclosed |
| CN-101346372-A | Aryl-isoxazol-4-yl-oxadiazole derivatives | HOFFMANN LA ROCHE (CH) | 2009-01-14 | — | — | CN | disclosed |