Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316093 | 0.86 | KMT2A (0.76) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL4846563 | 0.85 | KMT2A (0.73) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL3862966 | 0.85 | KMT2A (0.59) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL12310938 | 0.83 | KMT2A (0.58) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL7769050 | 0.83 | KMT2A (0.58) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL457706 | 0.82 | GPBAR1 (0.59) | SMN1; SMN2KMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL7771555 | 0.82 | KMT2A (0.60) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL1246411 | 0.82 | KMT2A (0.56) | SMN1; SMN2MAPK1KMT2AGAAMEN1 | |
| SCHEMBL3548012 | 0.82 | GPBAR1 (0.66) | KMT2AGAAMEN1ALDH1A1KDM4E | |
| SCHEMBL16333641 | 0.81 | ALDH1A1 (0.63) | SMN1; SMN2MAPK1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| US-7060710-B2 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABAA α5 subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 2006-06-13 | — | — | US | disclosed |
| US-7053219-B2 | Isoxazolopyridone derivatives and their use | BANYU PHARMACEUTICAL CO. LTD. (JP) | 2006-05-30 | — | — | US | disclosed |
| US-20040176407-A1 | Novel isoxazolopyridone derivatives and their use | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-09-09 | — | — | US | disclosed |
| EP-1408042-A1 | NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND USE THEREOF | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-20040006226-A1 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006226-A1 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands | GABRA5, GABRB1, GABRA4 | SMN1; SMN2 2855/4885MAPK1 4083/4885KMT2A 3319/4885 |
| US-20040176407-A1 | Novel isoxazolopyridone derivatives and their use | GRIN2A, GRM2, GRM1 | SMN1; SMN2 1300/4885MAPK1 1978/4885KMT2A 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.