Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164593 | 0.75 | GRM2 (0.47) | GRM5GAAGRM2HSD17B14KMT2A | |
| SCHEMBL2966992 | 0.67 | ALDH1A1 (0.76) | KMT2AHTTMEN1LMNASMN1; SMN2 | |
| SCHEMBL14407932 | 0.67 | ALDH1A1 (0.76) | KMT2AHTTMEN1LMNASMN1; SMN2 | |
| SCHEMBL15888794 | 0.66 | ALDH1A1 (0.59) | KMT2AHTTMEN1LMNASMN1; SMN2 | |
| SCHEMBL7811187 | 0.66 | SMN1; SMN2 (0.68) | HTTLMNASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL1584825 | 0.66 | F2 (0.59) | GAAKMT2AHTTLMNASMN1; SMN2 | |
| SCHEMBL6097936 | 0.64 | MAPT (0.49) | KMT2AHTTMEN1LMNASMN1; SMN2 | |
| SCHEMBL14099187 | 0.64 | LMNA (0.50) | KMT2AHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17716230 | 0.64 | KMT2A (0.64) | GAAKMT2AHTTKDM4EMEN1 | |
| SCHEMBL15679982 | 0.64 | CES2 (0.76) | GAAKMT2AHTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611502-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030918-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |