Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methdilazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | DRD1 | P21728 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | SCN1A | P35498 | 4/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | THPO | P40225 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL11737862 | 0.81 | CHRM2 (0.65) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Mequitazine SCHEMBL2355815 | 0.77 | CHRM2 (0.56) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL4814 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Dexbrompheniramine SCHEMBL29345 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL1604455 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL4314531 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Dexbrompheniramine SCHEMBL15516617 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL30182709 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL15516706 | 0.76 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Brompheniramine SCHEMBL6859988 | 0.75 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4CHRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933013-B2 | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory | NONO INC. (CA) | 2015-01-13 | — | — | US | claimed |