Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequitazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | SCN1A | P35498 | 3/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.56 |
| ▸ | HRH2 | P25021 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methdilazine SCHEMBL16348680 | 0.77 | CHRM2 (0.58) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Prochlorperazine SCHEMBL16099750 | 0.76 | DRD2 (0.63) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL4314182 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL4220 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL20956397 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL4219 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Dexchlorpheniramine SCHEMBL3538 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL29687335 | 0.75 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL22394593 | 0.75 | CHRM2 (0.76) | CHRM2SLC6A2SLC6A4CHRM1HRH1 | |
| Chlorpheniramine SCHEMBL10622596 | 0.74 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4CHRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011096941-A1 | METHOD OF TREATING OCULAR ALLERGY | ALCON RESEARCH, LTD. (US) | 2011-08-11 | — | — | WO | claimed |