Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162670 | 0.85 | MAOA (0.46) | HDAC1HDAC6MEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL161201 | 0.83 | MAOA (0.45) | HDAC1HDAC6ALDH1A1DRD2HTR7 | |
| Iodide SCHEMBL162027 | 0.83 | MAOA (0.45) | HDAC1HDAC6MEN1KMT2AALDH1A1 | |
| Phosphoric Acid SCHEMBL166017 | 0.82 | HDAC1 (0.49) | HDAC1HDAC6MEN1KMT2ASMN1; SMN2 | |
| Sulfuric Acid SCHEMBL158676 | 0.82 | HSD17B10 (0.49) | HDAC1HDAC6MEN1KMT2AALDH1A1 | |
| SCHEMBL158570 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6MEN1KMT2AHDAC3 | |
| Succinic Acid SCHEMBL161277 | 0.79 | NOTUM (0.54) | HDAC1HDAC6MEN1KMT2AALDH1A1 | |
| Malonic Acid SCHEMBL160931 | 0.79 | HDAC1 (0.50) | HDAC1HDAC6MEN1KMT2AMAPT | |
| Fumaric Acid SCHEMBL159723 | 0.78 | MEN1 (0.46) | HDAC1HDAC6MEN1KMT2AMAPT | |
| Maleic Acid SCHEMBL161823 | 0.78 | MEN1 (0.46) | HDAC1HDAC6MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |