SCHEMBL16353249

SCHEMBL16353249

C/C(=C\c1ccc(/C=C/c2ccc(N(c3ccc(C)cc3)c3ccc(/C=C/c4ccc(/C=C(\C)C(=O)O)cc4)cc3)cc2)cc1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.51
TRPM8 Q7Z2W7 2/20 0.48
FOS P01100 1/20 0.41
JUN P05412 1/20 0.41
CTDSP1 Q9GZU7 1/20 0.41
MAPT P10636 3/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 2/20 0.40
KMT2A Q03164 1/20 0.40
TBXAS1 P24557 3/20 0.38
NFE2L2 Q16236 1/20 0.38
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
ALOX5 P09917 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16353238 0.86 AKR1C3 (0.39) AKR1C3TRPM8FOSJUNCTDSP1
SCHEMBL9956060 0.85 AKR1C3 (0.69) AKR1C3TRPM8FOSJUNMAPT
SCHEMBL474138 0.85 AKR1C3 (0.69) AKR1C3TRPM8FOSJUNMAPT
SCHEMBL1920235 0.85 AKR1C3 (0.69) AKR1C3TRPM8FOSJUNMAPT
SCHEMBL11673262 0.83 AKR1C3 (0.69) AKR1C3TRPM8MAPTALDH1A1KMT2A
SCHEMBL4806412 0.80 AKR1C3 (0.62) AKR1C3TRPM8FOSJUNMAPT
SCHEMBL10059146 0.80 CISD1 (0.55) ALDH1A1CYP3A4HPGD
SCHEMBL11988098 0.80 TRPM8 (0.43) AKR1C3TRPM8FOSJUNCTDSP1
SCHEMBL5492449 0.79 NFE2L2 (0.56) TRPM8MAPTALDH1A1RAB9AKMT2A
SCHEMBL10015739 0.79 NFE2L2 (0.56) TRPM8MAPTALDH1A1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9304417-B2 Electrophotographic photoreceptor, electrophotographic image forming apparatus and process cartridge Konica Minolta, Inc. (JP) 2016-04-05 US disclosed
US-9304417-B2 Electrophotographic photoreceptor, electrophotographic image forming apparatus and process cartridge Konica Minolta, Inc. (JP) 2016-04-05 US disclosed
US-20140377694-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE Konica Minolta, Inc. (JP) 2014-12-25 US disclosed
US-20140377694-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE Konica Minolta, Inc. (JP) 2014-12-25 US disclosed