SCHEMBL16355183

SCHEMBL16355183

COc1cccc(C2=NC(c3ccccc3Cl)(n3c(-c4ccccc4Cl)nc(-c4cccc(C)c4)c3-c3cccc(OC)c3)N=C2c2cccc(OC)c2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 1/20 0.35
PDE10A Q9Y233 2/20 0.35
TEK Q02763 1/20 0.35
MAPT P10636 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ADORA2A P29274 3/20 0.34
ADORA1 P30542 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
POLB P06746 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
PDE2A O00408 1/20 0.34
NPSR1 Q6W5P4 2/20 0.34
USP2 O75604 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
MAOB P27338 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307530 0.96 PDE10A (0.37) PDE10ATEKADORA2AADORA1PDE2A
SCHEMBL16355184 0.90 PIK3CD (0.36) PDE10AMAPTADORA2AADORA1PDE2A
SCHEMBL16746559 0.89 CASR (0.37) ADORA2AADORA1KMT2ATSHRHSD17B10
SCHEMBL16355187 0.83 KDM4E (0.43) TEKMAPTSMN1; SMN2ADORA1ALDH1A1
SCHEMBL16355186 0.83 KDM4E (0.43) TEKMAPTSMN1; SMN2ADORA1ALDH1A1
SCHEMBL3101056 0.83 KDM4E (0.39) PDE10ATEKMAPTALDH1A1HPGD
SCHEMBL30358508 0.83 KDM4E (0.39) PDE10ATEKMAPTALDH1A1HPGD
SCHEMBL23816930 0.82 FABP4 (0.35) MAPTMAPK14
SCHEMBL3086363 0.81 KDM4E (0.38) PDE10ATEKMAPTADORA2AADORA1
SCHEMBL30358507 0.81 KDM4E (0.38) PDE10ATEKMAPTADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140374677-A1 COLORED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME, ORGANIC EL DISPLAY DEVICE, AND SOLID-STATE IMAGE SENSOR FUJIFILM CORPORATION (JP) 2014-12-25 US disclosed