SCHEMBL16355184

SCHEMBL16355184

COc1cccc(-c2c(-c3ccccc3Cl)nc(-c3ccccc3Cl)n2C2(c3ccccc3Cl)N=C(c3ccccc3)C(c3ccccc3)=N2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 4/20 0.36
ADORA2A P29274 3/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
PDE2A O00408 1/20 0.36
PDE10A Q9Y233 1/20 0.36
DPP4 P27487 2/20 0.36
ADORA1 P30542 2/20 0.35
GPBAR1 Q8TDU6 1/20 0.35
SLC16A3 O15427 1/20 0.35
SLC16A1 P53985 1/20 0.35
MCTS1 Q9ULC4 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
VDR P11473 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2B6 P20813 1/20 0.34
AHR P35869 1/20 0.34
NR1I3 Q14994 1/20 0.34
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307530 0.93 PDE10A (0.37) PIK3CDADORA2ANR1H2NR1H3PDE2A
SCHEMBL16355189 0.91 ALDH1A1 (0.40) PIK3CDPDE2APDE10AKDM4EL3MBTL1
SCHEMBL16355183 0.90 MAPK10 (0.35) PIK3CDADORA2APDE2APDE10ADPP4
SCHEMBL16355181 0.88 L3MBTL1 (0.43) PIK3CDADORA1KDM4EL3MBTL1TP53
SCHEMBL31734215 0.88 L3MBTL1 (0.43) PIK3CDADORA1KDM4EL3MBTL1TP53
SCHEMBL16355186 0.87 KDM4E (0.43) ADORA1KDM4EL3MBTL1MAPT
SCHEMBL16355187 0.87 KDM4E (0.43) ADORA1KDM4EL3MBTL1MAPT
SCHEMBL16355191 0.86 ALDH1A1 (0.41) PDE2APDE10ADPP4KDM4EL3MBTL1
SCHEMBL16746559 0.86 CASR (0.37) PIK3CDADORA2ANR1H2NR1H3ADORA1
SCHEMBL3101056 0.85 KDM4E (0.39) PIK3CDPDE2APDE10AKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140374677-A1 COLORED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME, ORGANIC EL DISPLAY DEVICE, AND SOLID-STATE IMAGE SENSOR FUJIFILM CORPORATION (JP) 2014-12-25 US disclosed
US-20140374677-A1 COLORED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME, ORGANIC EL DISPLAY DEVICE, AND SOLID-STATE IMAGE SENSOR FUJIFILM CORPORATION (JP) 2014-12-25 US disclosed