Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 2/20 | 0.45 |
| ▸ | GRB2 | P62993 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20235896 | 1.00 | TP53 (0.45) | TP53TSHRACACBGRB2SLC7A5 | |
| SCHEMBL10952481 | 0.88 | ACACB (0.44) | TP53TSHRACACBGRB2SLC7A5 | |
| SCHEMBL10564272 | 0.88 | GRB2 (0.49) | GRB2SLC7A5DPP4FAPDPP8 | |
| SCHEMBL6666822 | 0.86 | SLC7A5 (0.45) | GRB2SLC7A5DPP4DPP8DPP9 | |
| SCHEMBL7464405 | 0.86 | SLC7A5 (0.57) | SLC7A5ERAP2 | |
| SCHEMBL6957067 | 0.86 | ACACB (0.49) | TP53TSHRACACBGRB2DPP4 | |
| SCHEMBL594571 | 0.86 | SLC7A5 (0.57) | SLC7A5ERAP2 | |
| SCHEMBL630703 | 0.86 | SLC7A5 (0.57) | SLC7A5ERAP2 | |
| SCHEMBL17978114 | 0.86 | SLC7A5 (0.45) | ACACBGRB2SLC7A5DPP4FAP | |
| SCHEMBL3203564 | 0.86 | SLC7A5 (0.45) | GRB2SLC7A5DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849018-B | Piperazine derivatives | 安斯泰来制药株式会社 | 2021-02-23 | — | — | CN | disclosed |
| EP-3333165-B1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2019-09-18 | — | — | EP | disclosed |
| US-10301286-B2 | Piperazine derivative | ASTELLAS PHARMA INC. (JP) | 2019-05-28 | — | — | US | disclosed |
| US-10301286-B2 | Piperazine derivative | ASTELLAS PHARMA INC. (JP) | 2019-05-28 | — | — | US | disclosed |
| EP-3333165-A1 | PIPERAZINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2018-06-13 | — | — | EP | disclosed |
| US-9199927-B2 | Guanidinobenzoic acid compound | ASTELLAS PHARMA INC. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | SERPINB1, REN, SPINT2 | TP53 2642/4885TSHR 1376/4885ACACB 1017/4885 |
| US-10301286-B2 | Piperazine derivative | GPR4, MC4R, TRPC4 | TP53 3311/4885TSHR 728/4885ACACB 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.